If you have never traveled overseas, and especially in Europe, I would advise you to check the many useful websites online. You can save yourself many headaches.
Make sure you take note on how to travel safe and better, while travelling long distances on airplanes.
For those who have traveled but never to Italy, here I have a few suggestions for you.
We will talk about safety tips once you arrive at the hotel.
I have the habit of always making a copy of every document that travels with me including driver license, passports, credit cards, medical cards etc. (you can also take a picture of each one but copies are a must in case you lose your phone.
Of course you can email me if you need more info.